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Bioavailability is the biggest hurdle

Based on the content of water (~ 70%) in the skeletal muscle of HSB, the concentrations of creatine plus phosphocreatine in the skeletal muscle of HSB can be calculated to range from 130 to 165 mmol/L, which are about 3 times those in the skeletal muscle of growing pigs [31]

However, this should be evaluated by a physician to ensure a safe and appropriate treatment plan

Reck M, Kaiser R, Mellemgaard A, Douillard J-Y, Orlov S, Krzakowski M, et al

Based on available intake data, adult consumers are unlikely to exceed the TUL, except for regular users of food supplements containing high daily doses of selenium [93]

(2021) 89:e0073420